PART 2

The following note appeared in the ADA Research Notebook of a 1998 issue of Diabetes Forecast:

There's a new drug for type 2 diabetes on the horizon: BTS 67-582. Like sulfonylureas, BTS 67-582 spurs the pancreas to release more insulin, but it does this in different way than sulfonylureas do. (It affects different binding sites on the islet cells.) In a recent study, researchers found BTS 67-582 is safe and effective in controlling type 2 diabetes. They have also narrowed the search for the most effective and safe dosage...

A. (10 points) How does BTS 67-582 work? Hypothesize a reasonable mechanism for its action.

B. (10 points) Briefly describe how you might test your hypothesis and determine the mechanism. Indicate clearly what the results would show.


Think about the questions ñ its structure and its content - and possible answers, discuss them amongst yourselves, write down some ideas, and go to the next page.