Studying
Cell Biology Preface | Introduction to Problem Solving | Problem Sets | Acknowledgments |
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3. (15 pts) Gorgonian corals (the sea fans and their relatives) are not
preyed upon as heavily as many of their smaller cousins. Recently, scientists
have isolated a lethal neurotoxin, lophotoxin (LTX), from these creatures.
When administered to experimental animals, the first symptom observed
was ataxia (loss of muscular coordination), which was followed quickly
by general paralysis, curtailment of breathing and death. In isolated
nerve + muscle preparations, LTX in very low concentrations inhibited
neural stimulated contraction without affecting the muscle's ability to
respond to direct electrical stimulation. A. (10 pts) Postulate a mechanism for lophotoxin's effect that would
account for these observations.
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